Psoriasis and alcohol: is cutaneous ethanol one of the missing links?
- 18 November 2009
- journal article
- review article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 162 (4), 711-716
- https://doi.org/10.1111/j.1365-2133.2009.09595.x
Abstract
Many exogenous factors including excessive alcohol consumption have been associated with psoriasis, but the underlying mechanisms still remain elusive. Drinking worsens therapeutic compliance, and decreases the efficacy and increases the toxicity of systemic antipsoriatic treatments. Excess alcohol intake results in compromised immunity and increased risk of infections, but alcohol can induce proinflammatory cytokine production in various cell types and can increase mitogen-derived lymphocyte proliferation and lymphocyte activation. As we have previously reported, alcohol and one of its metabolites, acetone, induce keratinocyte proliferation and increase the mRNA levels of genes characteristic for proliferating keratinocytes, such as alpha5 integrin, cyclin D1 and keratinocyte growth factor receptor. Recently the correlation between blood and skin ethanol levels in humans was determined by a transdermal alcohol monitoring device, against the 'gold standard' breath alcohol readings. Based on transdermal alcohol measurements it can be concluded that cutaneous alcohol concentrations can reach levels that induce proinflammatory cytokine production and lymphocyte and keratinocyte proliferation in vitro. It is expected that the development of methodologies measuring transdermal ethanol will provide additional tools to evaluate how alcohol influences skin physiology and different dermatological conditions including psoriasis. Our review focuses on the possible link between alcohol misuse and psoriasis, particularly on the possible role of cutaneous ethanol in precipitating the disease.Keywords
This publication has 32 references indexed in Scilit:
- Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasisNature Genetics, 2009
- Alcohol and inflammation and immune responses: summary of the 2006 Alcohol and Immunology Research Interest Group (AIRIG) meetingAlcohol, 2008
- Alcohol consumption and psychological distress in patients with psoriasisBritish Journal of Dermatology, 2007
- Validity of Transdermal Alcohol Monitoring: Fixed and Self‐Regulated DosingAlcohol, Clinical and Experimental Research, 2006
- Overexpression of tumour necrosis factor-alpha-converting enzyme in psoriasisBritish Journal of Dermatology, 2005
- Sweat Ethanol Concentrations are Highly Correlated with Co‐Existing Blood Values in HumansExperimental Physiology, 1999
- Ethanol enhances the IFN-γ, TGF-α and IL-6 secretion in psoriatic co-culturesBritish Journal of Dermatology, 1996
- Ethanol Vapor above Skin: Determination by a Gas Sensor Instrument and Relationship with Plasma ConcentrationAlcohol, Clinical and Experimental Research, 1987
- Sweat‐Patch Testing Detects Inaccurate Self‐Reports of Alcohol ConsumptionAlcohol, Clinical and Experimental Research, 1984
- The Elimination of Ethyl Alcohol in Sweat1Skandinavisches Archiv Für Physiologie, 1936