Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin‐11
- 3 June 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 283 (2), 199-202
- https://doi.org/10.1016/0014-5793(91)80587-s
Abstract
A cDNA encoding a novel adipogenesis inhibitory factor (AGIF) that inhibits the process of adipogenesis in mouse 3T3-L1 preadipocytes was cloned from a cDNA library of the human bone marrow-derived stromal cell line KM-102. The cloned cDNA contains an open reading frame coding for an AGIF precursor of 199 amino acids. Analysis of the sequence of this cDNA revealed identity of this factor with a recently reported novel cytokine, designated interleukin-11 (IL-11). AGIF/IL-11 may play an important role in stromal cell-associated hematopoiesis through its regulatory action on adipocyte differentiation in the bone marrow microenvironment.Keywords
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