Abstract
The possible essentiality of fluoride for reproduction was studied in female mice fed a low-fluoride (103, 1319–1326], utilizing the same diet did result in an impairment of reproduction and the development of an anemic condition. The results of the present study suggest that the apparent essentiality of fluoride previously observed was due to a pharmacological effect of fluoride in improving iron utilization in a diet marginally sufficient in iron. The data do not support the previous claims of an essential role of fluoride in reproduction.