Chemical and Pharmacological Studies on N-Resulfated Heparin
- 1 April 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 109 (4), 901-905
- https://doi.org/10.3181/00379727-109-27372
Abstract
A method for synthesis of radioactive heparin of high unit activity and radioactivity has been described using a process of N-desulfation and N-resulfation. Comparison of the biological identity of the radioactive material with commercial heparin has been made. N-resulfated S35 heparin appears to be similar to biosynthetic S35 heparin in both its clearing and anticoagulant activity as well as its ultimate fate and distribution in the body.Keywords
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