Experimental Chemotherapy of Radiation Injury with Synthetic Lysophospholipid Analogs in Mice

Abstract

Synthetic lysophospholipids represent a variety of analogs of the naturally occurring 2-lysophosphatidylcholine. Some of these compounds showed significant therapeutic effects on the survival of mice following radiation injury when administered after various doses of whole-body X irradiation. Such therapeutic effects were discernible even when the treatment was given 6 h after irradiation, and both i.v. and oral application were effective. I.v. application of 2 .times. 25 mg/kg lysophospholipid after whole-body X irradiation around the LD50 resulted in significantly higher numbers of surviving animals. The mode of action remains speculative.