Klinefelter's Syndrome and Benign Prostatic Hypertrophy
- 19 October 1963
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 186 (3), 215-218
- https://doi.org/10.1001/jama.1963.03710030055009
Abstract
A patient is described who presented initially with benign prostatic hypertrophy and urinary retention. He underwent a prostatectomy and subsequent bilateral orchiectomy for microscopic "carcinoma of the prostate." Leydig cell hyperplasia was found on pathologic examination of the testes and evaluation for Klinefelter's syndrome was initiated. He was studied with buccal smears, polymorphonuclear leukocyte examinations, hormone excretion titers, short-term leukocyte tissue cultures with chromosome analyses, and, finally, by autopsy. He was proved to have Klinefelter's syndrome, benign prostatic hypertrophy, and, at autopsy, malignant carcinoid with widespread metastases; he did not have carcinoma of the prostate. The occurrence of this case raises many questions about the hormonal make-up of the Klinefelter's patient, about the stimulus for development of benign prostatic hypertrophy, and about the coincidental occurrence of solid tumors and chromosomal anomalies.Keywords
This publication has 8 references indexed in Scilit:
- Metabolism of Testosterone by the Human ProstateJAMA, 1963
- Thyroid Function in Patients with Aspermiogenesis and Testicular Tubular SclerosisNew England Journal of Medicine, 1963
- Effects of Estrogen and HCG on Androgen Synthesis by Human Testes1Journal of Clinical Endocrinology & Metabolism, 1962
- Synthesis of Testosterone by Subjects with Gonadal Dysgenesis and XXY Chromosome Constitution1Journal of Clinical Endocrinology & Metabolism, 1962
- The Effect of Hormonal Modification on Prostatic MorphologyJournal of Urology, 1962
- HYPOGONADISM IN YOUNG MEN (WITH EMPHASIS ON KLINEFELTER'S SYNDROME)Annals of Internal Medicine, 1961
- THE CHROMOSOME NUMBER OF MANHereditas, 1956
- A Morphological Distinction between Neurones of the Male and Female, and the Behaviour of the Nucleolar Satellite during Accelerated Nucleoprotein SynthesisNature, 1949