Technical Factors Influencing Permeability of Synovial Membrane in Rabbits.

Abstract

A critical method for evaluation of synovial permeability based on more than 5000 intra-articular injections in 1658 selected rabbits is presented. The method depends on accurate injection of the talocrural articulation, selection of animals for size and excretion pattern, and undisturbed circulation to the joint. Two workers in the same laboratory using identical techniques in testing the permeability effects of various compounds obtained data that show a high degree of correlation. A hitherto undescribed urinary bladder anomaly in rabbits is noted.