Physiological Significance of Secretin in the Pancreatic Bicarbonate Secretion
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 14 (1), 85-90
- https://doi.org/10.3109/00365527909179850
Abstract
The pancreatic response to physiological concentrations of secretin obtained after minute boluses of exogenous secretin was studied in 16 normal volunteers. Output of bicarbonate into the duodenum was measured by duodenal aspiration in 5 subjects and by endoscopic cannulation of the pancreatic duct in 11 subjects. Pure natural porcine secretin was injected intravenously in doses of 125, 250, and 500 fmol x kg−1 body weight (0.0013, 0.0027, and 0.0054 clinical units x kg−1). All three doses of secretin increased plasma secretin concentration, duodenal bicarbonate concentration, and duodenal bicarbonate output significantly. The bicarbonate output measured by the two techniques did not differ significantly. The increments in median plasma secretin concentration were 1.6, 3.0, and 6.4 pmol x l−1 after secretin, 125, 250 and 500 fmol x kg−1, and the corresponding 15-min bicarbonate output 283, 442, and 1435 μmol, respectively. The concentrations of secretin in plasma found after these doses of secretin are of the same order of magnitude as the secretin concentrations found during physiological conditions in man. It is concluded that the physiological concentrations of secretin influence pancreatic bicarbonate secretion.Keywords
This publication has 9 references indexed in Scilit:
- Secretion pattern of secretin in man: regulation by gastric acid.Gut, 1978
- Comparison of Juice Obtained during Duodenal Aspiration and Cannulation of the Main Pancreatic Duct after Stimulation with Exogenous Secretin in ManScandinavian Journal of Gastroenterology, 1978
- Pancreatic Response and Plasma Secretin Concentration during Infusion of Low Dose Secretin in ManScandinavian Journal of Gastroenterology, 1978
- pH Threshold for Release of Secretin in Normal Subjects and in Patients with Duodenal Ulcer and Patients with Chronic PancreatitisScandinavian Journal of Gastroenterology, 1978
- Neurohormonal control of pancreatic secretionGastroenterology, 1978
- Plasma Secretin Concentration and Pancreatic Exocrine Secretion after Intravenous Secretin or Intraduodenal HCL in Anaesthetized PigsScandinavian Journal of Gastroenterology, 1977
- Radioimmunoassay of secretin in plasmaScandinavian Journal of Clinical and Laboratory Investigation, 1977
- Production and Evaluation of Antibodies for Radioimmunoassay of SecretinScandinavian Journal of Clinical and Laboratory Investigation, 1976
- Acidity at different sites in the proximal duodenum of normal subjects and patients with duodenal ulcer.Gut, 1966