The particle-size of sulphadiazine produced by a solvent-change method
- 1 December 1971
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 23 (Supplement), 101S-110S
- https://doi.org/10.1111/j.2042-7158.1971.tb08777.x
Abstract
The factors affecting the particle-size of sulphadiazine produced by a solvent-change method of crystallization have been studied. The most important variables appear to be the degree of turbulence in the pipeline mixer used for the crystallization process, and the concentration of drug in the dimethylformamide injection solution. Mechanisms which can account for these, and other features of this crystallization method, are presented.Keywords
This publication has 10 references indexed in Scilit:
- The solubility of sulphadiazine in water-dimethylformamide mixturesJournal of Pharmacy and Pharmacology, 1968
- Particle Size of Drugs and Its Relationship to Absorption and ActivityJournal of Pharmaceutical Sciences, 1968
- Nucleation of Crystals from SolutionScience, 1965
- CRYSTALLIZATION EQUIPMENT Theory and Fundamentals of CrystallizationIndustrial & Engineering Chemistry, 1961
- The Limiting Equivalent Conductances of Hydrogen Chloride and Ammonium Chloride in DimethylformamideJournal of the Electrochemical Society, 1952
- The specific surface of powders. A modification of the theory of the air‐permeability methodJournal of the Society of Chemical Industry, 1947
- The specific surface of powders. A modification of the air‐permeability method for rapid routine testingJournal of the Society of Chemical Industry, 1943
- A Series of Aliphatic Dimethyl Amides1Journal of the American Chemical Society, 1937
- Theory of Coprecipitation. The Formation and Properties of Crystalline PrecipitatesThe Journal of Physical Chemistry, 1932
- The Precipitation Laws.Chemical Reviews, 1925