Intestinal factors affecting pancreatic exocrine secretion in the rat

Abstract

Perfusion of the rat duodenum or upper jejunum in situ with isotonic solutions of glucose, methionine, or sodium oleate produced neither an increase in flow rate nor change in the protein concentration of the pancreatic juice. Contrary to previou? findings by others, perfusion of the duodenum with HC1 elicited a significant increase in the flow rate of pancreatic juice and a concomitant, fall in its protein concentration. Perfusion of 8-cm jejunal segments showed that the peak flow rate decreased in the caudal segments and that perfusion of segments with origins more than 10 cm below the ligament of Treitz elicited no change in secretory rate. The findings suggest that the secretin mechanism is present in the rat and that the quantities of secretin present in the intestinal mucosa decrease caudally.