Heme Stimulation of Globin Synthesis in a Cell Free System

Abstract

In a cell-free system of pigeon erythrocyte nuclei high concentrations of oxygen inhibit globin synthesis because of the inhibition of heme synthesis, which is required for globin synthesis. The effect of heme in overcoming the inhibition of globin synthesis by oxygen is manifested only during the first few minutes of incubation. This period represents the time during which the system is being warmed from 4° to 37°C. The effect of heme seems to be upon some initial assembly or structural process.