Hydrolysis of Choline Esters by Liver
- 13 April 1945
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 101 (2624), 385-386
- https://doi.org/10.1126/science.101.2624.385
Abstract
A sample of rat serum (largely pseudo-cholin-esterase) had an acetylcholine (ACh) hydrolyzing capacity in arbitrary units of 2.98. Guinea pig liver extract had 0.16 units. A mixture of rat serum and guinea pig liver extract had an activity of 3.13. The two activities are thus additive. The low ACh hydrolysis by guinea pig liver is not due to the presence of inhibitors. Guinea pig liver split benzoylcholine 5-11 times as rapidly as ACh. The enzyme concerned is called benzoylcholineesterase. In other guinea pig tissues and organs assayed, the hydrolysis of ACh is greater than that of benzoylcholine.This publication has 4 references indexed in Scilit:
- On the Specificity of Choline Esterase in Nervous TissueScience, 1944
- Studies on cholinesteraseBiochemical Journal, 1943
- Cholinesterase and the behavior problem in Amblystoma. I. The relationship between the development of the enzyme and early motility. II. The effects of inhibiting cholinesteraseJournal of Experimental Zoology, 1943
- Über die fermentative Bildung von Benzamid und HippursäureHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1937