Sequential study of C 1 q-binding substances and of anti-DNA antibodies in (NZB × NZW)F1 mice: Evidence for an acute phase of the lupus disease in 2-month-old mice

Abstract
Longitudinal studies of C1 q and DNA‐binding substances were performed in sera from 38 (NZB × NZW)F1 female mice between days 39 and 150 of life. Results suggest a two‐phase evolution of circulating immune complexes and anti‐DNA antibodies in young (NZB × NZW)F1 mice and show the existence of an acute phase of the disease during the second month of life of these mice.