T lymphocyte response to H-2 mutants: cytotoxic effectors are Ly-1+2+.
- 1 July 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (7), 3455-3459
- https://doi.org/10.1073/pnas.76.7.3455
Abstract
The lymphocyte differentiaiton (Ly) antigen phenotype of cytotoxic effector T [thymus-derived cells] cells specific for H-2 [mouse] mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2Kba and H-2Dda alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis demonstrated that the mutant-specific T cells were Ly-1+2+. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1+2+, demonstrated that Ly-1+2+ T cells are immunocompetent. The nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of responsive T cells.Keywords
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