SPECIES SPECIFICITY OF LEUKOCYTIC PYROGENS
Open Access
- 1 October 1969
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 130 (4), 707-721
- https://doi.org/10.1084/jem.130.4.707
Abstract
Polymorphonuclear neutrophilic leukocytes of the dog, cat, and goat release leukocytic pyrogen under the same conditions as the heterophile polymorphonuclear leukocytes of the rabbit. The characteristics of the febrile response to an intravenous injection of homologous leukocytic pyrogen in all four species are very similar: a brisk monophasic fever reaching a peak between 30 and 50 min with smooth defervescence to the baseline by 3 hr. Shivering, which is not obvious in the rabbit, is noted in the dog, cat, and goat during the first 30 min. Quantitative differences in response reveal the cat to be the most sensitive of of these species to homologous leukocytic pyrogen, followed by the rabbit, dog, and goat.Keywords
This publication has 29 references indexed in Scilit:
- Studies on steroid feverJCI Insight, 1968
- Human Leukocyte Pyrogen Producing Fever in Rabbits.Experimental Biology and Medicine, 1966
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1966
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1964
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1963
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1962
- STUDIES ON THE PATHOGENESIS OF FEVER WITH INFLUENZAL VIRUSESThe Journal of Experimental Medicine, 1958
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1958
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1957
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1953