Evidence of gentamicin nephrotoxicity in patients with renal allografts.
- 2 August 1975
- Vol. 3 (5978), 278-281
- https://doi.org/10.1136/bmj.3.5978.278
Abstract
Renal damage was assessed by measuring urinary enzyme excretion in 180 patients with renal allografts. Thirty-six of these patients were studied during 53 courses of treatment with antimicrobial agents which was the only antimicrobial agent which was associated with an increase in urinary enzyme activity. There was usually also evidence of reduced renal function. Renal morphological changes similar to those produced by gentamicin in rats were observed in human allograft biopsy specimens obtained during gentamicin treatment.Keywords
This publication has 17 references indexed in Scilit:
- Urinary lysosomal glycosidases after renal allotransplantation: Correlation of enzyme excretion with allograft rejection and ischemiaClinica Chimica Acta; International Journal of Clinical Chemistry, 1973
- ACUTE RENAL FAILURE AFTER HIGH DOSES OF GENTAMICIN AND CEPHALOTHINThe Lancet, 1973
- Early Warning of Rejection?BMJ, 1973
- GENTAMICIN AND RENAL FAILUREThe Lancet, 1972
- Immunization with Live Types 7 and 4 Adenovirus Vaccines. I. Safety, Infectivity, Antigenicity, and Potency of Adenovirus Type 7 Vaccine in HumansThe Journal of Infectious Diseases, 1971
- CLINICAL RESEARCH EXPERIENCE WITH GENTAMICIN INCIDENCE OF ADVERSE REACTIONSThe Medical Journal of Australia, 1970
- Kinetic behaviour of calf-intestinal alkaline phosphatase with 4-methylumbelliferyl phosphateBiochemical Journal, 1965
- Gentamicin,1 a New Antibiotic Complex from MicromonosporaJournal of Medicinal Chemistry, 1963
- PHARMACOLOGY OF GENTAMICIN, A NEW BROAD-SPECTRUM ANTIBIOTIC.1963
- Studies on glucosaminidase. 4. The fluorimetric assay of N-acetyl-β-glucosaminidaseBiochemical Journal, 1961