POTENTIATION OF INSULIN ACTION: A PROBABLE MECHANISM FOR THE ANTI-DIABETIC ACTION OF SULFONYLUREA DRUGS

Abstract

Insulin action was assessed by measuring insulin-mediated glucose disposal (K_I) in 13 non-ketotic diabetic patients both before treatment and after normalization of plasma glucose by diet (5 patients) or sulfonylurea (glipizide) therapy (8 patients). While the K_I of the diet-treated group was unchanged by therapy, that of the glipizide-treated group was significantly increased. The data show that chronic glipizide therapy is associated with a potentiation of insulin action, which may account for the major anti-diabetic effect of this drug.