MUTAGENIC ACTIVATION OF NATURALLY OCCURRING EUGENOL VIA EPOXIDE-DIOL PATHWAY IN REPLICATIVE CULTURES OF EPITHELIAL-CELLS FROM RAT-LIVER
- 1 January 1977
- journal article
- research article
- Vol. 171 (1), 100-107
Abstract
The metabolism of eugenol via the epoxide-diol pathway was characterized by the incubation of this compound in replicative cultures of epithelial cells from sexed rat liver. It is a naturally occuring compound which is found as the 2nd metabolite of a known hepatic carcinogen, safrole. Eugenol did not appear as a mutagen while epoxyeugenol was mutagenic using the Ames Test.This publication has 3 references indexed in Scilit:
- Mutagenicity of metabolically activated benzo[a]anthracene 3,4-dihydrodiol: Evidence for bay region activation of carcinogenic polycyclic hydrocarbonsBiochemical and Biophysical Research Communications, 1976
- COMPARATIVE STUDIES WITH RAT-LIVER CELL LINES OF METABOLISM OF SAFROLE, A NATURAL HEPATOCARCINOGEN AND METABOLITES AND ANALOGS1976
- Anesthetic Action of Methyleugenol and Other Eugenol DerivativesPharmacology, 1976