Gastric Hypersecretion, Peptic Ulceration and Islet-Cell Tumor of the Pancreas (the Zollinger–Ellison Syndrome)

Abstract

THE association of noninsulin-producing islet-cell tumors of the pancreas and progressive peptic ulceration, recorded from time to time in the medical literature, until recently was thought to be coincidental. Zollinger and Ellison¹ described 2 patients with such findings, and reviewed 4 other cases collected from the literature. They suggested that there might be an etiologic relation between the islet-cell tumors and the occurrence of peptic ulcer. More recently Ellison² collected 24 cases from various sources and postulated the existence of a clinical entity consisting of gastric hypersecretion and hyperacidity, severe, recurrent and often atypically located peptic ulceration, and the presence . . .