Effect of a Tryptophan Deficient Diet on Brain Serotonin and Plasma Tryptophan Level.
- 1 July 1963
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 113 (3), 645-648
- https://doi.org/10.3181/00379727-113-28451
Abstract
Summary One hundred and eight female Wistar rats were placed on tryptophan sufficient or tryptophan deficient diets. Six animals from each group were sacrificed after 2 days, 4 days and multiples of 4 days. Plasma tryptophan level was found to reflect changes in brain serotonin level. Furthermore, plasma tryptophan and brain serotonin were significantly decreased after as little as 4 days on the tryptophan deficient diet. The levels of plasma tryptophan and brain serotonin were relatively constant from 4 to 28 days, at which time both showed further decreases.Keywords
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