Interpretation of subjective symptoms in double‐blind placebo‐controlled food challenges – interobserver reliability
- 16 February 2004
- Vol. 59 (3), 354-356
- https://doi.org/10.1111/j.1398-9995.2003.00437.x
Abstract
Subjective symptoms after food challenges are difficult to interpret and no standard is available. We discuss a strategy for how to interpret a diary. Furthermore, the interobserver reliability is evaluated.Diaries for 32 patients with subjective symptoms were used. The diaries were re-evaluated with a predefined strategy by three independent observers.The proportion of positives was 21.9% among the old diagnoses, according to the new approach 34.4% (observers I and II) and 37.5% (observer III) were positive. The new approach had high interobserver reliability (97 and 100%).The proportion of positives depends on how subjective symptoms are interpreted. Interpretations of subjective symptoms in diaries could be made with high interobserver reliability.Keywords
This publication has 15 references indexed in Scilit:
- Local allergic reaction in food-hypersensitive adults despite a lack of systemic food-specific IgEJournal of Allergy and Clinical Immunology, 2002
- A revised nomenclature for allergy: An EAACI position statement from the EAACI nomenclature task forceAllergy, 2001
- Controversial aspects of adverse reactions to foodAllergy, 1999
- Double blind, placebo controlled food reactions do not correlate to IgE allergy in the diagnosis of staple food related gastrointestinal symptoms.Gut, 1996
- Distinct patterns of cow's milk allergy in infancy defined by prolonged, two-stage double-blind, placebo-controlled food challengesClinical and Experimental Allergy, 1996
- Distinct patterns of cow's milk allergy in infancy defined by prolonged, two‐stage double‐blind, placebo‐controlled food challengesClinical and Experimental Allergy, 1996
- Adverse reactions to food*Allergy, 1995
- Egg and milk allergy in adultsAllergy, 1992
- Statistical methods for assessing observer variability in clinical measures.BMJ, 1992
- Hazards of challenge tests in atopic dermatitisAllergy, 1989