THE CREATININE, INULIN AND HIPPURATE CLEARANCE IN THE RAT

Abstract

Fifty-one large albino rats were studied in a 2 hr. clearance study in which the inulin, creatinine and hippurate clearances were obtained and compared. The creatinine, inulin, and hippurate clearances were proportional to the rate of urine flow. Moreover, the creatinine clearance was found to be the same as the inulin clearance at any given urine flow. At the minimal urine flow of 0.1 ml.-0.5 ml./100 g. of wt./ hr., the inulin, creatinine and hippurate clearances were 19.4 ml., 18.5 ml. and 94 ml./lOO g. of wt./hr. respectively. At the maximal urine flow of 1.50-2.0 ml., the same clearances were found to be 41.1 ml., 41.8 ml., and 209 ml./lOO g. of wt./hr. respectively. The creatinine clearance is an accurate measure of glomerular filtration in the rat.