COMPARISON OF THE HYPOGLYCEMIC ACTION OF TOLBUTAMIDE IN THE FOWL AND OTHER SPECIES12
- 1 August 1957
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 61 (2), 148-152
- https://doi.org/10.1210/endo-61-1-148
Abstract
Administration of tolbutamide by mouth or vein results in essentially the same hypoglycemic response in man, dog, rabbit, rat, chicken and duck. Whereas alloxanized dogs, rabbits and rats show no hypoglycemic response to tolbutamide, alloxanized chickens, depancreatized ducks and completely enterectomized ducks develop a brisk hypoglycemic response. Accordingly, the hypoglycemic response of the fowl to tolbutamide is independent of the presence of the pancreas and/or the discharge of insulin into the circulation.Keywords
This publication has 8 references indexed in Scilit:
- Ineffectiveness of Sulfonylureas in Alloxan Diabetic Rats.Experimental Biology and Medicine, 1956
- THE ACTION OF A SULFONYLUREA HYPOGLYCEMIC AGENT (ORINASE) IN EXTRAHEPATIC TISSUES1956
- ACUTE EFFECTS OF ORINASE ON PERIPHERAL GLUCOSE UTILIZATION1956
- SOME OBSERVATIONS ON THE MODE OF ACTION OF ORINASE1956
- HYPOGLYCEMIC EFFECTS OF 1-BUTYL-3-P-TOLUENE SULFONYLUREA GIVEN ORALLY IN HUMAN DIABETIC SUBJECTS (A PRELIMINARY REPORT)1956
- Hypoglycemic Action of Sulfanilamido-cyclopropylthiazole in Rabbits, and Its Reversal by AlloxanExperimental Biology and Medicine, 1946
- STUDIES ON NORMAL AND DEPANCREATIZED DOMESTIC DUCKSAmerican Journal of Physiology-Legacy Content, 1941
- THE INSULIN AND THE ZINC CONTENT OF NORMAL AND DIABETIC PANCREASJCI Insight, 1938