The effect of rise in temperature on the carbohydrate catabolism of cerebral cortex

Abstract

The rates of resplration and aerobic glycolysis in slices of brain cortex of the rabbit at 42[degree] are only slightly higher than these rates at 37[degree]. At 45[degree], however, the resplration ia increased by 100% above that at 37[degree] and the aerobic glycolysis is increased manyfold. The anaerobic glycolysis is also increased at 45[degree] although it falls extremely rapldly at this temp. The aerobic glycolysis at 45[degree] is due to the disproportionately great increase in glycolysis in relation to the increase in resplration and not to specific inhibition of the Pasteur effect. The effect of change of temp.on the rate of sugar destruction in brain (as calculated from the resplration and glycolysis) does not follow the Arrhenius law.