Role of Newer Medications for Bipolar Disorder
- 1 April 1996
- journal article
- review article
- Published by Wolters Kluwer Health in Journal of Clinical Psychopharmacology
- Vol. 16 (SUPPLEMENT), 48S-55S
- https://doi.org/10.1097/00004714-199604001-00006
Abstract
The quest for additional effective therapies for bipolar study commenced in the 1960s, even before regulatory approval of lithium. This was driven by the recognition that patient response to lithium varied from excellent to poor; thus, significant numbers of patients faced its frequent adverse effects and risks without sustaining any benefit. These needed advances have been slowed by the unusual difficulties of studying bipolar disorder in controlled, rigorously designed protocols. These difficulties are reviewed both from the perspective of their effects on research and on clinical practice. In addition, the results of two blinded, placebo-controlled studies of divalproex in the treatment of acute mania are compared with results from earlier open and comparator studies. The comparisons indicate that open-study results with divalproex and other forms of valproic acid have yielded results quite similar to those observed under rigorous study conditions. Whereas substantial evidence exists regarding the efficacy of divalproex and carbamazepine and their roles in treating patients with bipolar disorder, studies evaluating other putative mood-stabilizing agents and antidepressants in bipolar disorder are few in number and inconsistent in results. With few exceptions, studies of these latter drugs do not provide clear guidelines for treatment.Keywords
This publication has 41 references indexed in Scilit:
- The Efficacy and Safety of Divalproex Sodium in the Treatment of Acute Mania in Adolescents and Young AdultsJournal of Clinical Psychopharmacology, 1995
- Recurrent Affective Syndromes in Bipolar and Unipolar Mood Disorders at Follow-UpThe British Journal of Psychiatry, 1995
- The National Depressive and Manic-depressive Association (DMDA) survey of bipolar membersJournal of Affective Disorders, 1994
- Lithium Monotherapy: Miracle, Myth and MisunderstandingPsychiatric Annals, 1994
- Rate and Predictors of Prepubertal Bipolarity during Follow-up of 6- to 12-Year-Old Depressed ChildrenJournal of the American Academy of Child & Adolescent Psychiatry, 1994
- Efficacy of Divalproex vs Lithium and Placebo in the Treatment of ManiaJAMA, 1994
- Thyroid abnormalities during lithium treatmentActa Psychiatrica Scandinavica, 1991
- Comparison of Standard and Low Serum Levels of Lithium for Maintenance Treatment of Bipolar DisorderNew England Journal of Medicine, 1989
- Patient and Physician Attitudes Toward LithiumArchives of General Psychiatry, 1979
- EFFICACY OF LITHIUM AS ACUTE TREATMENT OF MANIC-DEPRESSIVE ILLNESSThe Lancet, 1971