Effects of Adenosine and Adenine Nucleotides on the Postsynaptic Potential and on the Formation of Cyclic Adenosine 3', 5'-Monophosphate from Radioactive Adenosine Triphosphate in Guinea Pig Olfactory Cortex Slices
- 1 January 1975
- journal article
- Published by Japan Academy in Proceedings of the Japan Academy
- Vol. 51 (6), 495-500
- https://doi.org/10.2183/pjab1945.51.495
Abstract
Addition of adenosine or its nucleotides to the medium immediately decreased the amplitude of postsynaptic potential (N-wave) and enhanced the formation of 14C-cyclic AMP from prelabelled ATP pool in the olfactory cortex slices of guinea pig. After a removal of the agents, the inhibition on the potential was rapidly recovered and the amount of cyclic AMP was diminished back to the original level. Theophyline inhibited both effects of the agents. The physiological roles of adenosine and adenine nucleotides were discussed in view of a possibility of neurotransmitters or modulators in CNS as well as the mediation of their action through cyclic AMP.Keywords
This publication has 12 references indexed in Scilit:
- Inhibitory Action of Adenosine and Adenine Nucleotides on the Postsynapptic Potential of Olfactory Cortex Slices of the Guinea PigProceedings of the Japan Academy, 1975
- UPTAKE AND RELEASE OF [14C]ADENINE DERIVATIVES AT BEDS OF MAMMALIAN CORTICAL SYNAPTOSOMES IN A SUPERFUSION SYSTEMJournal of Neurochemistry, 1974
- SUBCELLULAR LOCALIZATION OF [14C]ADENINE DERIVATIVES NEWLY‐FORMED IN CEREBRAL TISSUES AND THE EFFECTS OF ELECTRICAL EXCITATIONJournal of Neurochemistry, 1973
- Release of [14C]adenine derivatives from isolated subsystems of the guinea pig brain: Actions of electrical stimulation and of papaverineBrain Research, 1973
- Adenosine 3′,5′-Monophosphate: Electrophysiological Evidence for a Role in Synaptic TransmissionScience, 1972
- The effect of adenosine on the release of the transmitter from the phrenic nerve of the ratThe Journal of Physiology, 1972
- Metabolism of [14C]adenine and derivatives by cerebral tissues, superfused and electrically stimulatedBiochemical Journal, 1972
- Stimulated Formation of Adenosine 3′,5′-Cyclic Phosphate in Cerebral Cortex: Synergism between Electrical Activity and Biogenic AminesProceedings of the National Academy of Sciences, 1970
- Adenosine 3′,5′-Monophosphate-Dependent Protein Kinase from BrainScience, 1969
- THE EFFECT OF ELECTRICAL STIMULATION UPON THE ACCUMULATION OF ADENOSINE 3′,5′‐PHOSPHATE IN ISOLATED CEREBRAL TISSUEJournal of Neurochemistry, 1969