Capillary Permeability in Cutaneous Tissue

Abstract

Paaske, W. P. Capillary permeability in cutaneous tissue. Acta physiol. scand. 1976. 98. 492–499. Capillary permeability in cutaneous tissue was determined by the single injection, external counting method. A rabbit abdominal skin preparation was developed. After local vasodilatation, 5 μ1 (400 μCi) ⁵¹Cr-EDTA was administered intraarterially by a special bolus injection technique, and the response curve was recorded by external registration. The capillary diffusion capacity (the permeability-surface area product) for ⁵¹Cr-EDTA amounted to 3.7 m1/100 g·min at a capillary extraction of 0.59 and a plasma flow of 4.8 m1/100 gemin. The permeability coefficient for ⁵¹Cr-EDTA in cutaneous tissue was calculated to 0.9.10^-5 cm/s assuming a capillary surface area of 70 cm²/g.