Stable growth transformation of human T lymphocytes by herpesvirus saimiri.
- 1 April 1992
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 89 (7), 3116-3119
- https://doi.org/10.1073/pnas.89.7.3116
Abstract
Herpesvirus saimiri induces T-cell lymphomas in various species of New World monkeys and in rabbits, and it is able to immortalize monkey T lymphocytes in vitro. Sequences responsible for these effects have been localized to a region of the genome that varies significantly among the virus subgroups A, B, and C. We now report that infection of human blood lymphocytes and thymocytes with strains of subgroup C, in contrast to viruses of the other subgroups, yields continuously proliferating T-cell lines with the phenotype of mature CD4- or CD8-positive cells. Infection with strains of Herpes-virus saimiri subgroup C can thus be used to generate human T-cell lines for a variety of immunological and developmental studies.Keywords
This publication has 15 references indexed in Scilit:
- Persistence of Selectable Herpesvirus Saimiri in Various Human Haematopoietic and Epithelial Cell LinesJournal of General Virology, 1991
- A pair of selectable herpesvirus vectors for simultaneous gene expression in human lymphoid cellsGene, 1991
- The divergence between two oncogenic Herpesvirus saimiri strains in a genomic region related to the transforming phenotypeVirology, 1990
- Structural organization of the conserved gene block of Herpesvirus saimiri coding for DNA polymerase, glycoprotein B, and major DNA binding proteinVirology, 1990
- Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector.Proceedings of the National Academy of Sciences, 1989
- Four novel U RNAs are encoded by a herpesvirusCell, 1988
- Herpesvirus saimiri strain 11 immortalizes a restricted marmoset T8 lymphocyte subpopulation in vitro.The Journal of Experimental Medicine, 1986
- A Region of the Herpesvirus saimiri Genome Required for OncogenicityScience, 1985
- Natural killer activity of lymphoid cells isolated from human ascitic ovarian tumorsInternational Journal of Cancer, 1980
- Acute Lymphocytic Leukemia in Owl Monkeys Inoculated with Herpesvirus saimiriScience, 1971