Failure of factor VIII inhibitor bypassing activity (Feiba) to secure haemostasis in haemophilic patients with antibodies.
Open Access
- 1 November 1978
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 31 (11), 1102-1105
- https://doi.org/10.1136/jcp.31.11.1102
Abstract
Factor IX concentrates have been widely advocated in the treatment of haemophilic patients with factor VIII inhibitors. Five such patients were given the 'activated' factor IX concentrate--factor VIII inhibitor bypassing activity (Feiba)--for 14 separate bleeding episodes. In six of the episodes, including two with external blood loss, bleeding progressed in spite of treatment. In none of the other eight episodes was there a prompt response, and it was not possible to ascribe a definite therapeutic effect.This publication has 21 references indexed in Scilit:
- Resistance to Activated F IX Concentrate (FEIBA)Scandinavian Journal of Haematology, 2009
- Notfallbehandlung von Blutungskomplikationen bei Hemmkörper-Hämophilie mit aktivierten Prothrombinkomplex-KonzentratenDeutsche Medizinische Wochenschrift (1946), 1977
- DISSEMINATED INTRAVASCULAR COAGULATION AND INFUSION OF FACTOR-VIII-INHIBITOR BYPASSING ACTIVITYThe Lancet, 1977
- Successful treatment with prothrombin complex concentrate of postoperative bleeding in a haemophiliac with a factor VIII inhibitor.BMJ, 1976
- Antihemophilic factor inhibitors. Management with prothrombin complex concentratesJAMA, 1976
- FACTOR-VIII INHIBITOR BYPASSING ACTIVITYThe Lancet, 1976
- Prothrombin complex concentrate (Konyne) in the treatment of hemophilic patients with factor VIII inhibitorsThe Journal of Pediatrics, 1976
- CONCENTRATES OF CLOTTING-FACTOR IXThe Lancet, 1976
- PROTHROMBIN-COMPLEX CONCENTRATE IN TREATMENT OF CLASSICAL HÆMOPHILIA WITH FACTOR-VIII ANTIBODYThe Lancet, 1975
- A Method for the Study of Antihaemophilic Globulin Inhibitors with Reference to Six CasesBritish Journal of Haematology, 1959