Use of Thiosulfate Clearance As a Measure of Glomerular Filtration Rate in Acidotic Dogs.

Abstract

In acidosis produced by the oral admn. of NH4CI, the simultaneously detd. creatinine and thiosulfate clearances are identical within limits of exptl. error. The view of Gilman, Philips and Koelle that the thiosulfate clearance constitutes an adequate measure of filtration rate in the normal animal is thereby extended to include the acidotic animal. The admn. of thiosulfate is without significant effect on either filtration rate (creatinine clearance) or minimum effective renal plasma flow (p-aminohip-purate clearance). Since thiosulfate is devoid of buffer properties, its use is preferable to that of creatinine in assessing renal function in animals in acidosis in which titratable acid excretion rates are to be detd.