Influence of Glucose Concentration on the Action of Insulin

Abstract

The effect of plasma glucose concn. on the rate of glucose disappearance and oxidation was determined in the extrahepatic tissues of insulinized rabbits. A 10-fold increase in glucose concn. produces a 2-fold increase in transfer rate. The oxidation of glucose parallels the glucose disappearance rate but this is more likely due to the increased amt. of glucose transferred intracellularly.