A study on the use of phenylacetyl disulfide in the solid‐phase synthesis of oligodeoxynucleoside phosphorothioates
- 1 January 1991
- journal article
- research article
- Published by Wiley in Recueil des Travaux Chimiques des Pays-Bas
- Vol. 110 (7-8), 325-331
- https://doi.org/10.1002/recl.19911100705
Abstract
Sulfurization of protected [i.e., 2‐cyanoethyl, methyl and 2‐(4‐nitrophenyl)ethyl] internucleosidic phosphite triesters can be conveniently executed with the easily accessible reagent, phenylacetyl disulfide (1). High‐quality oligodeoxynucleotides containing predetermined combinations of natural and phosphorothioate linkages can be obtained via a solid‐phase approach by using reagent 1 and 2‐(4‐nitrophenyl)ethyl‐protected phosphoramidites.This publication has 29 references indexed in Scilit:
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