The Effect of Adrenergic Blocking Agents and of Chlorpromazine on Blood Pressure Increase by Vasopressin and Angiotensin

Abstract

The influence of the adrenergic blocking agents hydergine, dibenamine and tolazoline and of chlorpromazine on the mean arterial pressure response to vasopressin, angiotensin and barium chloride in anaesthetised dogs was investigated. Adrenergic blocking agents potentiate significantly the pressure response to vasopressin while leaving the responses to angiotensin and barium chloride unaltered. Chloropromazine potentiates the responses to both vasopressin and angiotensin. This potentiation is not due to blood pressure lowering produced by adrenergic blockade or by chlorpromazine.