The effect of iron status on glyceraldehyde 3-phosphate dehydrogenase expression in rat liver
- 13 February 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 359 (2), 126-128
- https://doi.org/10.1016/0014-5793(95)00023-3
Abstract
The influence of iron status on glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene transcription, mRNA levels and distribution was determined in whole liver samples from adult Wistar rats. While iron loading did not alter GAPDH expression, iron deficiency evoked a 2.3-fold increase in the steady-state level of liver GAPDH mRNA, but did not affect gene transcription or intracellular localisation of the message. Therefore, the over-expression of GAPDH mRNA in iron deficiency is probably due to increased message stability.Keywords
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