Axoplasmic transport block reduces ectopic impulse generation in injured peripheral nerves

Abstract

Afferent fibers ending in nerve end neuromas in rats generate a substantial ectopic dischange and are sensitive to light pressure and to circulating adrenaline [epinephrine]. Treatment of the nerve with cholchicine or vinblastine at the time of the nerve section results in a dose-dependent reduction in the extent of this discharge. Such treatment also reduced neuroma discharge that had already gotten underway.