POTENT TUMOR-INITIATING ACTIVITY OF THE 3,4-DIHYDRODIOL OF 7,12-DIMETHYLBENZ(A)ANTHRACENE IN MOUSE SKIN
- 1 January 1979
- journal article
- research article
- Vol. 39 (6), 1934-1936
Abstract
The abilities of the racemic trans-3,4-,5,6-, and 8,9-dihydrodiols of 7,12-dimethylbenz(a)anthracene to initiate skin tumors in mice were determined by using a 2-stage system of tumorigenesis. The 7,12-dimethylbenz(a)anthracene trans-3,4-dihydrodiol was much more active as a tumor initiator than the parent hydrocarbon. The 7,12-dimethylbenz(a)anthracene trans-5,6- and 8,9-dihydrodiols were essentially inactive as skin tumor initiators. The 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene is a proximal carcinogen and the bay region diol-epoxide may be the ultimate carcinogenic form of DMBA.This publication has 27 references indexed in Scilit:
- Mutagenicity and cytotoxicity of benz[ a ]anthracene diol epoxides and tetrahydro-epoxides: Exceptional activity of the bay region 1,2-epoxidesProceedings of the National Academy of Sciences, 1977
- Metabolic activation of the carcinogen 7,12-dimethylbenz[a]anthracene for DNA bindingBiochemical and Biophysical Research Communications, 1977
- MARKED DIFFERENCES IN TUMOR-INITIATING ACTIVITY OF OPTICALLY PURE (+)- AND (-)-TRANS-7,8-DIHYDROXY-7,8-DIHYDROBENZO(A)PYRENE ON MOUSE SKIN1977
- Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyreneBritish Journal of Cancer, 1976
- (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene: a potent skin carcinogen when applied topically to mice.Proceedings of the National Academy of Sciences, 1976
- Mutagenicity of metabolically activated benzo[a]anthracene 3,4-dihydrodiol: Evidence for bay region activation of carcinogenic polycyclic hydrocarbonsBiochemical and Biophysical Research Communications, 1976
- Benzo[ a ]pyrene Diol Epoxides as Intermediates in Nucleic Acid Binding in Vitro and in VivoScience, 1976
- (+/-)-7alpha,8beta-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)-pyrene is an intermediate in the metabolism and binding to DNA of benzo(a)pyrene.Proceedings of the National Academy of Sciences, 1976
- Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.Proceedings of the National Academy of Sciences, 1976
- LACK OF CARCINOGENICITY OF 4-HYDROXYBENZO(A)PYRENE,5-HYDROXYBENZO(A)PYRENE,6-HYDROXYBENZOA(A) PYRENE, 7-HYDROXYBENZO(A)PYRENE, 8-HYDROXYBENZO(A)PYRENE, 9-HYDROXYBENZO(A)PYRENE, AND 10-HYDROXYBENZO(A)PYRENE ON MOUSE SKIN1976