Some Antagonists of Atropine-Like Psychotomimetics

Abstract

The peripheral pharmacological effects of an anti-acetylcholine psychotomimetic drug, ethylpiperidylcyclopentylphenyl glycolate hydrochloride (JB-329) were found to be essentially similar to those of atropine. Both drugs inhibited parasympathetic effects and acetylcholine responses and produced potentiation of the pressor responses to adrenaline and noradrenaline. The compound tetrahydroaminoacridine, shown to be an antagonist of JB-329, was studied and its actions were compared with those of other cholinesterase inhibitors. Certain glycolic acid derivatives, some of which have been shown to antagonise the effects of JB-329, were also studied and their pharmacology and interactions are presented. The mode of action of the antagonists are discussed.