Experimental barbiturate dependence
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 57 (2), 137-144
- https://doi.org/10.1007/bf00426878
Abstract
A method for testing a rat's physical-dependence liability to sedaditive-hypnotic agents and for evaluating that dependence was studied by using the method. Rats received phenobarbital- or barbital-admixed food on a graded-increase dosage schedule over 30–40 days. Manifestations of CNS-suppressing action of either drug (e.g., systemic muscle relaxation, motor incoordination, staggering gait, and ptosis) persisted day and night during the drug medication. Twenty-four to 48 h after withdrawal of either drug, abstinence symptoms (e.g., muscle fasciculation, nuchal twitching, vocalization, increased irritability, ataxia, hyperthermia, and clonic-tonic and grand mal-type convulsions) were evidenced in all animals (N=6), some of which died after convulsions. These withdrawal signs in rats were classified and found to be closely correlated with the magnitude of weight loss during the withdrawal. The classification provides a basis for quantitatively assessing physical-dependence liability. The data obtained in the present study suggest that rats, like dogs and monkeys, are suitable experimental animals for tests in early stages of dependence liability, and that the administration of drug-admixed food is a useful method of developing dependence on both barbiturate and morphine-type drugs.Keywords
This publication has 16 references indexed in Scilit:
- A method for bioassay of physical dependence on sedative drugs in dogPsychopharmacology, 1976
- Physical Dependence on Morphine, Phenobarbital and Diazepam in Rats by Drug-Admixed Food IngestionThe Japanese Journal of Pharmacology, 1975
- Comparison of drug dependence formation in naive and drug dependence-experienced ratsFolia Pharmacologica Japonica, 1975
- Studies on dependence of short acting drugs in ratsFolia Pharmacologica Japonica, 1975
- A screening procedure for barbital type physical dependence liability of psychotropic drugsFolia Pharmacologica Japonica, 1973
- The effects of drugs on barbiturate withdrawal convulsions in the ratJournal of Pharmacy and Pharmacology, 1970
- Barbiturate withdrawal in white ratsInternational Journal of Neuropharmacology, 1966
- Barbiturate withdrawal convulsions in decerebellate dogsInternational Journal of Neuropharmacology, 1964
- Withdrawal reactions from chlordiazepoxide (?Librium?)Psychopharmacology, 1961
- A Note on a Simple Apparatus for Detecting Neurological Deficit in Rats and Mice**College of Pharmacy, University of Nebraska, Lincoln 8.Journal of the American Pharmaceutical Association (Scientific ed.), 1957