Effect of bile salt on pancreatic secretion of the dog

Abstract

In the dog, secretion of the resting pancreas is affected little if at all by sodium dehydrocholate. On the other hand, secretin-stimulated pancreatic secretion is increased greatly by this bile salt; double vagotomy did not change this effect. The stimulating effect of the bile salt on secretin-stimulated pancreatic secretion was diminished greatly when both substances were mixed and administered immediately. There is a difference between effects of different brands of sodium dehydrocholate on the stimulated secretion of the dog's pancreas.