Metabolism of Interferon: Hepatic Clearance of Native and Desialylated Interferon
- 1 June 1977
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 35 (3), 525-534
- https://doi.org/10.1099/0022-1317-35-3-525
Abstract
Summary The effect of removal of sialic acid on the survival of rabbit serum and urinary interferon (IF) has been investigated in isolated, perfused rabbit liver preparations. In contrast with native IF, which may be already partially desialylated, IF freed of 80 to 90% of its sialic acid was rapidly cleared from the perfusate of normal livers, or livers pre-treated with actinomycin D. The results suggest that the mechanism of IF catabolism by the liver is similar to that reported for several other circulating glycoproteins.This publication has 7 references indexed in Scilit:
- Recovery and identification of interferon in the rabbit urineCellular and Molecular Life Sciences, 1967
- An Interferon-Like Viral Inhibitor in Body Fluids of Endotoxin-Injected Rabbits.Experimental Biology and Medicine, 1966
- EFFECT OF ACTINOMYCIN D ON VIRUS AND ENDOTOXIN-INDUCED INTERFERONLIKE INHIBITORS IN RABBITSProceedings of the National Academy of Sciences, 1965
- Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoidsBiochemical Journal, 1961
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951
- THE DOMINANT ROLE OF THE LIVER IN PLASMA PROTEIN SYNTHESISThe Journal of Experimental Medicine, 1951
- DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTIONJournal of Biological Chemistry, 1949