Glomerular Capillary Thrombosis and Acute Renal Failure after Epsilon-Amino Caproic Acid Therapy

Abstract

WITH increased awareness of the hemorrhagic syndromes produced by spontaneous intravascular coagulation or fibrinolysis, there has been increased use of epsilon-amino caproic acid (EACA, Amicar) as a therapeutic agent. This, in turn, has led to recognition of a number of its toxic side effects.^{1 , 2} Hypotension, one of its known side effects,^{1 , 2} could produce acute tubular necrosis and thus precipitate acute renal failure. Intraureteral clot formation, reported after the use of EACA for treatment of hematuria in patients with hemophilia,^{1 2 3} if bilateral could also result in anuria and renal failure. The following case illustrates the development of oliguria and renal failure . . .