DIRECT ACTION OF ESTROGEN ON THE OVARY OF THE IMMATURE RAT1
- 1 January 1961
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 68 (1), 115-120
- https://doi.org/10.1210/endo-68-1-115
Abstract
Crystalline estradiol or stilbestrol was applied to one ovary of the immature rat leaving the other ovary untreated. The estrogen treated ovary exhibited several unilaterally differential responses: (1) a greater increase in weight, (2) formation of corpora lutea, (3) an increased responsiveness to endogenous and exogenous gonadotrophins. In control experiments crystalline testosterone or progesterone was applied to one ovary with, or without, estradiol being placed on the other ovary. These experiments demonstrate that estrogen has a local stimulatory effect within the ovary as well as a systemic effect via the pituitary.Keywords
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- QUANTITATIVE RESPONSE OF THE RAT OVARY TO PITUITARY GONADOTROPIN AS MODIFIED BY ESTROGEN1Endocrinology, 1959
- Effect of Estrogens and Androgens Alone and in Combination with Chorionic Gonadotropin on the Ovary of the Hypophysectomized RatScience, 1940
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