Familial transmission of schizotypal and borderline personality disorders

Abstract

The risk for psychiatric disorders in the first-degree relative of 36 probands with schizotypal personality disorder (13 definite, 23 probable), 17 probands with borderline personality disorder (2 definite, 15 probable), and 90 normal control probands were determined. The relatives of probands with schizotypal personality disorder without a concurrent diagnosis of borderline personality disorder had a significantly greater risk for schizotypal personality disorder than the relatives of normal control probands, borderline probands, or schizotypal probands with coexisting borderline personality disorder. The relatives of borderline probands had a significantly greater risk for definite and probable borderline personality disorder than the relatives of normal control probands.