THE RENAL CLEARANCE OF ESSENTIAL AMINO ACIDS: ARGININE, HISTIDINE, LYSINE AND METHIONINE

Abstract

Renal clearance studies of arginine, histidine, lysine and methionine in dogs indicated individual differences in the tubular reabsorption of these amino acids. At plasma levels up to 10 and 50 times respectively that of the post-absorptive state reabsorption of histidine and methionine essentially was complete and no evidence was available that the maximal rate of tubular reabsorption had been reached. The capacity for tubular reabsorption of arginine and lysine was markedly less than that for histidine and methionine. The values were readily obtainable and were found to be in the order of 11 mg./min. for arginine and 13 mg./min. for lysine.