Retinal Dystrophy: Development Retarded by Galactose Feeding in Spontaneously Hypertensive Rats
- 24 January 1986
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 231 (4736), 376-378
- https://doi.org/10.1126/science.3941900
Abstract
Retinal photoreceptor cell dystrophies have been widely observed in humans and in animals, but pathogenetic mechanisms are known in only a few such disorders, and successful therapeutic intervention has been reported in fewer still. Spontaneously hypertensive albino rats develop a retinal photoreceptor cell dystrophy with onset late in the first year or early in the second year of life. Between 60 and 70 percent of the animals are affected. A substantial reduction in the prevalence and severity of the dystrophy occurred in such animals whose diet contained 30 percent (by weight) D-galactose. Neither an inhibitor of the enzyme aldose reductase, present in the diet, nor diabetes mellitus, induced by streptozotocin, had any statistically significant influence on the dystrophy. Ambient light and systolic blood pressure levels also did not seem to influence the course of the disorder. The mechanism by which galactose exerts its effect is unknown, but a mutant enzyme with an elevated Michaelis constant (Km) for galactose is plausible.This publication has 15 references indexed in Scilit:
- Gyrate Atrophy of the Choroid and Retina: Improved Visual Function Following Reduction of Plasma Ornithine by DietScience, 1980
- Involvement of cyclic GMP phosphodiesterase activator in an hereditary retinal degenerationNature, 1979
- Rod-Cone Dysplasia in Irish Setters: A Defect in Cyclic GMP Metabolism in Visual CellsScience, 1978
- Deficient L-ornithine: 2-oxoacid aminotransferase activity in cultured fibroblasts from a patient with gyrate atrophy of the retinaBiochemical and Biophysical Research Communications, 1977
- Cyclic GMP Accumulation Causes Degeneration of Photoreceptor Cells: Simulation of an Inherited DiseaseScience, 1977
- Inherited Retinal Dystrophy: Primary Defect in Pigment Epithelium Determined with Experimental Rat ChimerasScience, 1976
- Cyclic Guanosine Monophosphate: Elevation in Degenerating Photoreceptor Cells of the C3H Mouse RetinaScience, 1974
- CYCLIC-NUCLEOTIDE PHOSPHODIESTERASEThe Journal of cell biology, 1973
- THE ROLE OF THE PIGMENT EPITHELIUM IN THE ETIOLOGY OF INHERITED RETINAL DYSTROPHY IN THE RATThe Journal of cell biology, 1971
- INHERITED RETINAL DYSTROPHY IN THE RATThe Journal of cell biology, 1962