Nucleotide Sequences of the Joint between the L and S Segments of Herpes Simplex Virus Types 1 and 2
- 1 August 1981
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 55 (2), 315-331
- https://doi.org/10.1099/0022-1317-55-2-315
Abstract
The a sequence of herpes simplex virus (HSV) is present as a direct repeat at the genomic termini and also in inverted orientation at the joint between the L [long] and S [short] segments. DNA sequences were determined for the joint regions of the genomes of HSV-1 and HSV-2, and relative to these sequences the genomic termini are, in both cases, located close to a short direct repeat of 17-21 base pairs (bp) at the b-a and a-c junctions. The HSV-1 joint region contains 3 separate tandem direct reiterations of short sequences, (12, 16 and 17 bp in strain 17) and size heterogeneity in the a and c sequences is apparently due to variable copy numbers of these repeated units. A considerable part of the HSV-1 joint region probably does not code for polypeptide.This publication has 22 references indexed in Scilit:
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