Agranulocytosis Induced by Trimeprazine

Abstract

PHENOTHIAZINE derivatives have long been known to have serious toxic effects in a small number of susceptible persons. Among these reactions are hepatic damage, epileptic seizures, Parkinson's disease, various skin disorders and hematopoietic depression.^{1 2 3 4 5 6 7 8 9 10} It is the purpose of this report to call attention to the hematotoxic potentialities of a new member of this pharmacologic family, trimeprazine. The drug has been under clinical trial for nearly two years and has recently been released to the medical profession. It shares a number of the useful properties of the phenothiazine drugs, and has been found to be particularly effective as an antipruritic . . .