Imported Malaria in HIV-Infected Patients Enrolled in the ANRS CO4 FHDH Study
- 1 September 2008
- journal article
- research article
- Published by Wolters Kluwer Health in JAIDS Journal of Acquired Immune Deficiency Syndromes
- Vol. 49 (1), 55-60
- https://doi.org/10.1097/qai.0b013e31817e635b
Abstract
Background: To describe episodes of imported malaria in human immunodeficiency virus type 1-infected patients and to study the risk factors for severe Plasmodium falciparum malaria. Methods: Patients enrolled in the French Hospital Database on HIV who were diagnosed with a first episode of malaria between 1996 and 2003 were included. The severity of P. falciparum imported malaria was graded with World Health Organization criteria. Geographic areas were classified according to P. falciparum chemoresistance. Risk factors for severe malaria were identified with logistic regression. Results: We studied 190 patients infected by P. falciparum in 178 cases. All but four of the patients were infected in sub-Saharan Africa, and half were returning from a country with a high P. falciparum chloroquine resistance. Their median age was 37.5 years, and 57% came from a country endemic with malaria. The median CD4 cell count was 299/mm3, and the median plasma human immunodeficiency virus type 1 RNA load was 4.5 log10 copies/mL. Sixty-five (36.5%) episodes of P. falciparum malaria were severe. Severe imported malaria was associated with CD4 cells/mm3 P. falciparum infection was acquired in areas of high prevalence of chemoresistance.Keywords
This publication has 31 references indexed in Scilit:
- Understanding and improving access to prompt and effective malaria treatment and care in rural Tanzania: the ACCESS ProgrammeMalaria Journal, 2007
- Risk Factors for Imported FatalPlasmodium falciparumMalaria, France, 1996–2003Emerging Infectious Diseases, 2007
- Increased Prevalence of Severe Malaria in HIV-Infected Adults in South AfricaClinical Infectious Diseases, 2005
- The global distribution of clinical episodes of Plasmodium falciparum malariaNature, 2005
- pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparumMolecular Microbiology, 2005
- Effect of malaria on HIV-1 progression and transmissionThe Lancet, 2005
- Höheres Lebensalter: Risikofaktor für einen schweren Verlauf der MalariaDeutsche Medizinische Wochenschrift (1946), 2003
- Age as a Risk Factor for SeverePlasmodium falciparumMalaria in Nonimmune PatientsClinical Infectious Diseases, 2001
- Malaria Chemoprophylaxis in the Age of Drug Resistance. I. Currently Recommended Drug RegimensClinical Infectious Diseases, 2001
- Imported Malaria in The Bronx: Review of 51 Cases Recorded from 1986 to 1991Clinical Infectious Diseases, 1992