Lymphokines (MIF) in the serum of patients with sarcoidosis and cutaneous granuloma annulare
- 1 November 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 95 (5), 481-485
- https://doi.org/10.1111/j.1365-2133.1976.tb00857.x
Abstract
Serum MIF [migration inhibitory factor] activity was studied in 10 patients with sarcoidosis, 14 with granuloma annulare, 4 with necrobiosis lipoidica and 9 with various dermatological diseases. Positive MIF activity was found in the sera of 9 of the 10 patients with sarcoidosis and 11 of the 14 patients with granuloma annulare. Delayed hypersensitivity tests were negative in all 9 of the patients with sarcoidosis who had serum MIF activity, and were positive in only 3 patients with cutaneous sarcoid lesions. One of 4 patients with necrobiosis lipoidica demonstrated minimal serum MIF activity. Data on serum lymphokine activity in sarcoidosis and granuloma annulare suggest that these 2 diseases are related to delayed hypersensitivity mechanisms.This publication has 10 references indexed in Scilit:
- Granuloma annulare: direct immunofluorescence studyBritish Journal of Dermatology, 1976
- Macrophage inhibitor factor (MIF) in cutaneous lymphoproliferative diseasesBritish Journal of Dermatology, 1976
- Serum Migration-Inhibitory Activity in Patients with Lymphoproliferative DiseasesNew England Journal of Medicine, 1974
- ASSAY FOR INHIBITION OF MACROPHAGE MIGRATIONPublished by Elsevier ,1971
- In Vitro Lymphocyte Response of Patients with Immunologic Deficiency DiseasesNew England Journal of Medicine, 1970
- Studies on migration inhibitory factor (MIF): Recovery of MIF activity after purification by gel filtration and disc electrophoresisCellular Immunology, 1970
- Altered Immunologic Activity in SarcoidosisAnnals of Internal Medicine, 1966