PARTIAL CHARACTERIZATION OF URINARY ADRENOCORTICAL STEROIDS IN ADRENAL HYPERPLASIA 1

Abstract

A study, utilizing both paper and column chromatographic techaiques, revealed an abnormally low excretion of Compound F and its metabolites in the urine of patients with adrenal hyperplasia. This strongly supports the concept of a deficient synthesis of Compound F by the diseased adrenal cortex. Characteristic excretion of pregnane-3,17,20-triol in large quantities suggests a deficient conversion of 17-hydroxyprogesterone into Compound F. Large amounts of steroids oxygenated at C-11 and at C-17 and "normal" quantities of 21-hydroxylated steroids were detected in the urine of several affected individuals.